اثرات 4 هفته بی‌تمرینی به دنبال 12 هفته تمرین‌های هوازی بر تغییرات آلانین آمینوترانسفراز، آسپارتات آمینوترانسفراز، آلکالین فسفاتاز و سطح چربی‌های خون در موش‌های یائسه

  Background and Objectives : Previous studies confirm the effects of strenuous exercise on elevated levels of liver enzymes, but the effect of detraining especially on liver tissue enzymes is unclear. The purpose of this study was to examine the effects of a 12-week aerobic training course followed by a 4-week detraining period on on liver tissue enzymes including Alanine aminotransferase(ALT), Alkaline phosphatase(ALP) , Aspartate aminotransferase (AST) and blood lipids level   Materials and Methods : In this experimental study, 80 Wistar rats aged 21 months old with a menopausal period of 3 months were included and then were divided randomly into three gropus control, continuous and interval groups. Experimental groups received continuous and/or interval training courses on treadmill for twelve weeks follwed by a 4-week detraining period . Hepatic biopsy samples were taken before and at the of end of sixth, twelfth and sixteenth weeks. ALT, AST and ALP levels and blood lipids (HDL-C and LDL-C) concentrations were measured by an automatic analyzer (Olympus AU 800) and enzymatic methods, respectively.   Results : In both continuous and interval groups, after the 4-week detraining period , the levels of ALT, AST and ALP de creased significantly compared with the values of 6 and 12 weeks aerobic training courses (p=0.001). However, the levels of ALT, and AST were still higher in these two groups after this period compared to the similar values of the pre-test (p=0.028 and p=0.019 for ALT respectively, and p=0.05 and p=0.001 for AST respectively). In addition, after 6 and 12 weeks continuous and aerobic interval training courses, the LDL-C levels decreased markedly compared with the control group ( p=0.009, p=0.001 and p=0.001, respectively in continuous group and p=0.023, p=0.001 and p=0.001, respectively in the aerobic interval group, and the HDL-C levels significantly increased (p=0.001).   Conclusion: These findings suggest that liver enzymes levels decreased significantly after a 12-week aerobic training course followed by a 4-week detraining period . In addition, the results showed that the LDL-C levels decreased and the HDL-C increased significantly after 6 and 12 weeks training courses.   Key words : Liver enzymes, Detraining , Menopausal rats, Liver stress     Funding : This research was funded by Mazandaran University.   Conflict of interest : None declared.   Ethical approval : The ethics committee of Mazandaran university approved the study   How to cite this article : Barzegarzadeh H , Dabidi Roshan V . Effects of a 12-Week aerobic Training Course Followed by a 4-Week Detraining Period on Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase and Blood Lipids Level Changes in Menopausal Rats . J Rafsanjan Univ Med Scie 2012 11(3): 207-18. [Farsi]